Aging, lifestyle and dementia

Devin Wahl; Samantha M. Solon-Biet; Victoria C. Cogger; Luigi Fontana; Stephen J. Simpson; David G. Le Couteur; Rosilene V. Ribeiro

Neurobiology of Disease (Oct 2019)

Aging, lifestyle and dementia

Devin Wahl,
Samantha M. Solon-Biet,
Victoria C. Cogger,
Luigi Fontana,
Stephen J. Simpson,
David G. Le Couteur,
Rosilene V. Ribeiro

Affiliations

Devin Wahl: Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord 2139, Australia; Corresponding authors at: Charles Perkins Centre, The University of Sydney, Johns Hopkins Drive, Camperdown, NSW, Australia.
Samantha M. Solon-Biet: Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord 2139, Australia
Victoria C. Cogger: Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord 2139, Australia
Luigi Fontana: Charles Perkins Centre, University of Sydney, Sydney 2006, Australia
Stephen J. Simpson: Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney 2006, Australia
David G. Le Couteur: Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; Aging and Alzheimers Institute, ANZAC Research Institute, Concord Clinical School/Sydney Medical School, Concord 2139, Australia; Corresponding authors at: Charles Perkins Centre, The University of Sydney, Johns Hopkins Drive, Camperdown, NSW, Australia.
Rosilene V. Ribeiro: Charles Perkins Centre, University of Sydney, Sydney 2006, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney 2006, Australia

Journal volume & issue: Vol. 130
p. 104481

Abstract

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Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders, and neurodegenerative disease. There is emerging evidence that interventions that improve metabolic health with aging may also be effective for brain health. The most robust interventions are non-pharmacological and include limiting calorie or protein intake, increasing aerobic exercise, or environmental enrichment. In humans, dietary patterns including the Mediterranean, Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) and Okinawan diets are associated with improved age-related health and may reduce neurodegenerative disease including dementia. Rapamycin, metformin and resveratrol act on nutrient sensing pathways that improve cardiometabolic health and decrease the risk for age-associated disease. There is some evidence that they may reduce the risk for dementia in rodents. There is a growing recognition that improving metabolic function may be an effective way to optimize brain health during aging.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

About the journal

Abstract

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