GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling

• Vanessa A. N. Kraft,
• Carla T. Bezjian,
• Susanne Pfeiffer,
• Larissa Ringelstetter,
• Constanze Müller,
• Fereshteh Zandkarimi,
• Juliane Merl-Pham,
• Xuanwen Bao,
• Natasa Anastasov,
• Johanna Kössl,
• Stefanie Brandner,
• Jacob D. Daniels,
• Philippe Schmitt-Kopplin,
• Stefanie M. Hauck,
• Brent R. Stockwell,
• Kamyar Hadian,
• Joel A. Schick

Affiliations

Vanessa A. N. Kraft

Institute of Molecular Toxicology and Pharmacology, Genetics and Cellular Engineering Group, HelmholtzZentrum Muenchen, Neuherberg, Germany

Carla T. Bezjian

Department of Chemistry, Columbia University, New York, New York, United States

Susanne Pfeiffer

Institute of Molecular Toxicology and Pharmacology, Genetics and Cellular Engineering Group, HelmholtzZentrum Muenchen, Neuherberg, Germany

Larissa Ringelstetter

Institute of Molecular Toxicology and Pharmacology, Assay Development and Screening Platform, HelmholtzZentrum Muenchen, Neuherberg, Germany

Constanze Müller

Research Unit Analytical BioGeoChemistry, HelmholtzZentrum Muenchen, Neuherberg, Germany

Fereshteh Zandkarimi

Department of Biological Sciences, Columbia University, New York, New York, United States

Juliane Merl-Pham

Research Unit Protein Science, HelmholtzZentrum Muenchen, Neuherberg, Germany

Xuanwen Bao

Institute of Radiation Biology, HelmholtzZentrum Muenchen, Neuherberg, Germany

Natasa Anastasov

Institute of Radiation Biology, HelmholtzZentrum Muenchen, Neuherberg, Germany

Johanna Kössl

Institute of Molecular Toxicology and Pharmacology, Genetics and Cellular Engineering Group, HelmholtzZentrum Muenchen, Neuherberg, Germany

Stefanie Brandner

Institute of Molecular Toxicology and Pharmacology, Assay Development and Screening Platform, HelmholtzZentrum Muenchen, Neuherberg, Germany

Jacob D. Daniels

Department of Pharmacology, Columbia University, New York, New York, United States

Philippe Schmitt-Kopplin

Research Unit Analytical BioGeoChemistry, HelmholtzZentrum Muenchen, Neuherberg, Germany

Stefanie M. Hauck

Research Unit Protein Science, HelmholtzZentrum Muenchen, Neuherberg, Germany

Brent R. Stockwell

Department of Chemistry, Columbia University, New York, New York, United States

Kamyar Hadian

Institute of Molecular Toxicology and Pharmacology, Assay Development and Screening Platform, HelmholtzZentrum Muenchen, Neuherberg, Germany

Joel A. Schick

Institute of Molecular Toxicology and Pharmacology, Genetics and Cellular Engineering Group, HelmholtzZentrum Muenchen, Neuherberg, Germany