Intermediate Vancomycin Susceptibility in a Community-associated MRSA Clone

Abstract

We describe a case of treatment failure caused by a strain of USA300 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with intermediate susceptibility to vancomycin and reduced susceptibility to daptomycin. The strain was isolated from the bone of a 56-year-old man with lumbar osteomyelitis after a 6-week treatment course of vancomycin for catheter-associated septic thrombophlebitis.

Keywords

• Staphylococcus aureus
• vancomycin resistance
• methicillin resistance
• community-acquired infections
• Panton-Valentine leukocidin
• daptomycin