Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

Wilfried Posch; Marta Bermejo-Jambrina; Marion Steger; Christina Witting; Gabriel Diem; Paul Hörtnagl; Hubert Hackl; Cornelia Lass-Flörl; Lukas A. Huber; Teunis B. H. Geijtenbeek; Doris Wilflingseder

doi:10.1128/mBio.02408-21

mBio (Oct 2021)

Complement Potentiates Immune Sensing of HIV-1 and Early Type I Interferon Responses

Wilfried Posch,
Marta Bermejo-Jambrina,
Marion Steger,
Christina Witting,
Gabriel Diem,
Paul Hörtnagl,
Hubert Hackl,
Cornelia Lass-Flörl,
Lukas A. Huber,
Teunis B. H. Geijtenbeek,
Doris Wilflingseder

Affiliations

Wilfried Posch: Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Marta Bermejo-Jambrina: Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Marion Steger: Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Christina Witting: Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Gabriel Diem: Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Paul Hörtnagl: Central Institute for Blood Transfusion and Immunological Department, Innsbruck, Austria
Hubert Hackl: Institute of Bioinformatics, Biocenter Innsbruck, Medical University of Innsbruck, Innsbruck, Austria
Cornelia Lass-Flörl: Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria
Lukas A. Huber: Institute of Cell Biology, Biocenter Innsbruck, Medical University of Innsbruck, Innsbruck, Austria
Teunis B. H. Geijtenbeek: Department of Experimental Immunology, Amsterdam Infection and Immunity Institute, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Doris Wilflingseder: ORCiD; Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria

DOI: https://doi.org/10.1128/mBio.02408-21
Journal volume & issue: Vol. 12, no. 5

Abstract

Read online

Importantly, our study highlights an unusual target on DCs—the α chain of complement receptor 4 (CR4) (CD11c)—for therapeutic interventions in HIV-1 treatment. Targeting CD11c on DCs mediated a potent antiviral immune response via clustering of CR4 and CCR5 and subsequent opening of an antiviral recognition pathway in DCs via MAVS.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal