Caveolin-1: a multifaceted driver of breast cancer progression and its application in clinical treatment

Abstract

Xian-Ling Qian,1,2 Yi-Hang Pan,1,2 Qi-Yuan Huang,1,3 Yu-Bo Shi,1 Qing-Yun Huang,1 Zhen-Zhen Hu,1,4 Li-Xia Xiong1,4 1Department of Pathophysiology, Basic Medical College, Nanchang University, Nanchang 330006, China; 2First Clinical Medical College, Nanchang University, Nanchang 330006, China; 3Second Clinical Medical College, Nanchang University, Nanchang 330006, China; 4Jiangxi Province Key Laboratory of Tumor Pathogenesis and Molecular Pathology, Nanchang 330006, China Abstract: Human breast cancer is one of the most frequent cancer diseases and causes of death among female population worldwide. It appears at a high incidence and has a high malignancy, mortality, recurrence rate and poor prognosis. Caveolin-1 (Cav1) is the main component of caveolae and participates in various biological events. More and more experimental studies have shown that Cav1 plays a critical role in the progression of breast cancer including cell proliferation, apoptosis, autophagy, invasion, migration and breast cancer metastasis. Besides, Cav1 has been found to be involved in chemotherapeutics and radiotherapy resistance, which are still the principal problems encountered in clinical breast cancer treatment. In addition, stromal Cav1 may be a potential indicator for breast cancer patients’ prognosis. In the current review, we cover the state-of-the-art study, development and progress on Cav1 and breast cancer, altogether describing the role of Cav1 in breast cancer progression and application in clinical treatment, in the hope of providing a basis for further research and promoting CAV1 gene as a potential target to diagnose and treat aggressive breast cancers. Keywords: breast cancer, caveolin-1, migration, metastasis, prognosis, invasion

Keywords

• breast cancer
• caveolin-1
• migration
• metastasis
• prognosis