Recent Advances of Organ-on-a-Chip in Cancer Modeling Research
Xingxing Liu,
Qiuping Su,
Xiaoyu Zhang,
Wenjian Yang,
Junhua Ning,
Kangle Jia,
Jinlan Xin,
Huanling Li,
Longfei Yu,
Yuheng Liao,
Diming Zhang
Affiliations
Xingxing Liu
Guangdong Provincial Key Laboratory of Industrial Surfactant, Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510075, China
Qiuping Su
Guangdong Provincial Key Laboratory of Industrial Surfactant, Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510075, China
Xiaoyu Zhang
Research Center for Intelligent Sensing Systems, Zhejiang Laboratory, Hangzhou 311100, China
Wenjian Yang
Research Center for Intelligent Sensing Systems, Zhejiang Laboratory, Hangzhou 311100, China
Junhua Ning
Guangdong Provincial Key Laboratory of Industrial Surfactant, Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510075, China
Kangle Jia
Guangdong Provincial Key Laboratory of Industrial Surfactant, Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510075, China
Jinlan Xin
Guangdong Provincial Key Laboratory of Industrial Surfactant, Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510075, China
Huanling Li
Guangdong Provincial Key Laboratory of Industrial Surfactant, Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510075, China
Longfei Yu
Guangdong Provincial Key Laboratory of Industrial Surfactant, Institute of Chemical Engineering, Guangdong Academy of Sciences, Guangzhou 510075, China
Yuheng Liao
Research Center for Intelligent Sensing Systems, Zhejiang Laboratory, Hangzhou 311100, China
Diming Zhang
Research Center for Intelligent Sensing Systems, Zhejiang Laboratory, Hangzhou 311100, China
Although many studies have focused on oncology and therapeutics in cancer, cancer remains one of the leading causes of death worldwide. Due to the unclear molecular mechanism and complex in vivo microenvironment of tumors, it is challenging to reveal the nature of cancer and develop effective therapeutics. Therefore, the development of new methods to explore the role of heterogeneous TME in individual patients’ cancer drug response is urgently needed and critical for the effective therapeutic management of cancer. The organ-on-chip (OoC) platform, which integrates the technology of 3D cell culture, tissue engineering, and microfluidics, is emerging as a new method to simulate the critical structures of the in vivo tumor microenvironment and functional characteristics. It overcomes the failure of traditional 2D/3D cell culture models and preclinical animal models to completely replicate the complex TME of human tumors. As a brand-new technology, OoC is of great significance for the realization of personalized treatment and the development of new drugs. This review discusses the recent advances of OoC in cancer biology studies. It focuses on the design principles of OoC devices and associated applications in cancer modeling. The challenges for the future development of this field are also summarized in this review. This review displays the broad applications of OoC technique and has reference value for oncology development.
