Nucleus (2019-08-01)

ISOLPHARM, a new production method of high specific activity beta-emitting radionuclides as radiopharmaceutical precursors

  • Alberto Andrighetto,
  • Francesca Borgna,
  • Michele Ballan,
  • Stefano Corradetti,
  • Elisa Vettorato,
  • Alberto Monetti,
  • Massimo Rossignoli,
  • Mattia Manzolaro,
  • Daniele Scarpa,
  • Gianfranco Prete,
  • Fabiana Gramegna,
  • Nicola Realdon

Journal volume & issue
Vol. 0, no. 65
pp. 32 – 35


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At INFN-LNL (Istituto Nazionale di Fisica Nucleare- Laboratori Nazionali di Legnaro) SPES (Selective Production of Exotic Species), a new facility for the production of radioactive ion beams is being constructed at INFN-LNL (Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali di Legnaro). Radioactive ion beams of neutron-rich nuclei with high purity, in the range of mass between 80 and 160 amu, will be produced by nuclear reactions induced by 40 MeV protons from a cyclotron. The goal of the ISOLPHARM project is to provide a feasibility study for an innovative technology for the production of extremely very high specific activity beta emitting radionuclides as radiopharmaceutical precursors. The ISOL method, adopted in the ISOLPHARM project (a branch of the SPES project), gives the possibility of obtaining pure isobaric beams. In this way, no isotopic contaminations will be present in the beam and afterwards in a proper trapping substrate. The ground-breaking idea of the ISOLPHARM method was granted an International patent (INFN).