The m6A reader PRRC2A is essential for meiosis I completion during spermatogenesis

Xinshui Tan; Caihong Zheng; Yinghua Zhuang; Pengpeng Jin; Fengchao Wang

doi:10.1038/s41467-023-37252-y

Nature Communications (Mar 2023)

The m6A reader PRRC2A is essential for meiosis I completion during spermatogenesis

Xinshui Tan,
Caihong Zheng,
Yinghua Zhuang,
Pengpeng Jin,
Fengchao Wang

Affiliations

Xinshui Tan: Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences
Caihong Zheng: Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, and China National Center for Bioinformation
Yinghua Zhuang: National Institute of Biological Sciences
Pengpeng Jin: National Institute of Biological Sciences
Fengchao Wang: Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences

DOI: https://doi.org/10.1038/s41467-023-37252-y
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 18

Abstract

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Modification of RNA with m6A has been shown to be important during spermatogenesis. Here they identify post-transcriptional functions of PRRC2A, showing it promotes transcriptome transition from spermatogonia to spermatocytes and the translation of genes related to cell division.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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