Hypertension in Pregnancy (Jul 2021)

Pro-BNP Levels and Its Prognostic Role in Chronic Hypertensive Pregnancies: A Prospective Case-Control Study From A Tertiary Care Hospital

  • Mehmet Akif Erdol,
  • Atakan Tanacan,
  • Hasan Eroglu,
  • Nazan Vanli Tonyali,
  • Mehmet Erdogan,
  • Aykan Yucel,
  • Nuray Yazihan,
  • Dilek Sahin

DOI
https://doi.org/10.1080/10641955.2021.1939712
Journal volume & issue
Vol. 40, no. 3
pp. 202 – 208

Abstract

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Background: This study aimed to investigate the prognostic value of N-terminal B-type natriuretic peptide (NT-proBNP) in pregnancies with isolated chronic hypertension (HT). Method: 34 pregnant women with chronic HT and 40normotensive controls were enrolled. The association between plasma NT-proBNP levels obtained in the first trimester and perinatal complications were evaluated. Results: NT-proBNP levelsstrongly predicted low birth weight (AUC=0.842, p<0.001). NT-proBNP and birth weight were negatively correlated (r= -0.323, p=0.005). NT-proBNP was found to be an individual determinant of low birth weight in univariate analysis (OR:1.03; 95%CI:1.01-1.04). Conclusion: NT-proBNP levels can be useful to predict low birth weight in pregnancies with chronic HT.

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