Impact of anti‐obesity medication initiation and duration on weight loss in a comprehensive weight loss programme

Abstract

Summary Objective This retrospective study aimed to evaluate the impact of anti‐obesity medication (AOM) initiation, usage and duration on weight loss in a 72‐week precision obesity programme. The type of AOM, diet and exercise plan was chosen based upon an individual's biological and psychosocial needs. The 72‐week study duration allowed for a fair investigation of the downstream impact of delayed versus early AOM initiation. Methods Participants, aged ≥18 years with body mass index ≥30 kg m−2, enrolled from 1 March 2015 to 1 April 2017, were included. Subgroups were assigned by AOM usage (users versus non‐users, early [before 8 weeks] versus delayed [after 8 weeks] AOM initiation and short [5% weight loss (P = 0.006). A higher proportion of users lost ≥15% of weight (45.1% vs. 19.0%; P < 0.001). Mean percentage reduction in weight was greater for early versus delayed starters (−17.60 ± 5.3% vs. −13.95 ± 5.5%; P = 0.024), and longer AOM usage trended towards increased weight loss. Conclusion Early initiation of AOM may enhance weight loss.

Keywords

• obesity treatment
• weight loss
• weight management programme
• weight‐reducing drugs