PLoS ONE (Jan 2019)

Mean platelet volume is more important than age for defining reference intervals of platelet counts.

  • Till Ittermann,
  • Martin A Feig,
  • Astrid Petersmann,
  • Dörte Radke,
  • Andreas Greinacher,
  • Henry Völzke,
  • Thomas Thiele

DOI
https://doi.org/10.1371/journal.pone.0213658
Journal volume & issue
Vol. 14, no. 3
p. e0213658

Abstract

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BackgroundPlatelet count is known to be associated with sex, age and mean platelet volume (MPV). Sex and age were proposed for adjustment of platelet count reference intervals, but MPV is currently not used for further adjustment. We investigated the association of MPV, age and sex with platelet counts and established individualized reference ranges respecting MPV.MethodsThe association of platelet count with age, sex and MPV was assessed in healthy participants (n = 3,033 individuals; 1,542 women) in the cross-sectional population-based cohort Study of Health in Pomerania. Reference intervals respecting age, sex, and MPV were estimated using quantile regressions for the 2.5th and 97.5th percentile.ResultsWomen had higher platelet counts than men (239 vs. 207 x109/L, pConclusionMPV and sex have a stronger association with platelet count than age. MPV should be considered to adjust platelet count reference intervals and needs to be respected as confounder for platelet counts in epidemiological studies and clinical practice.