Nature Communications (May 2021)
CaMKII oxidation is a critical performance/disease trade-off acquired at the dawn of vertebrate evolution
- Qinchuan Wang,
- Erick O. Hernández-Ochoa,
- Meera C. Viswanathan,
- Ian D. Blum,
- Danh C. Do,
- Jonathan M. Granger,
- Kevin R. Murphy,
- An-Chi Wei,
- Susan Aja,
- Naili Liu,
- Corina M. Antonescu,
- Liliana D. Florea,
- C. Conover Talbot,
- David Mohr,
- Kathryn R. Wagner,
- Sergi Regot,
- Richard M. Lovering,
- Peisong Gao,
- Mario A. Bianchet,
- Mark N. Wu,
- Anthony Cammarato,
- Martin F. Schneider,
- Gabriel S. Bever,
- Mark E. Anderson
Affiliations
- Qinchuan Wang
- Department of Medicine, Johns Hopkins School of Medicine
- Erick O. Hernández-Ochoa
- Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine
- Meera C. Viswanathan
- Department of Medicine, Johns Hopkins School of Medicine
- Ian D. Blum
- Department of Neurology, Johns Hopkins School of Medicine
- Danh C. Do
- Department of Medicine, Johns Hopkins School of Medicine
- Jonathan M. Granger
- Department of Medicine, Johns Hopkins School of Medicine
- Kevin R. Murphy
- Department of Medicine, Johns Hopkins School of Medicine
- An-Chi Wei
- Department of Electrical Engineering, Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University
- Susan Aja
- Department of Neuroscience, Johns Hopkins School of Medicine
- Naili Liu
- Center for Genetic Muscle Disorders, Kennedy Krieger Institute
- Corina M. Antonescu
- Johns Hopkins Computational Biology Consulting Core
- Liliana D. Florea
- Johns Hopkins Computational Biology Consulting Core
- C. Conover Talbot
- Institute for Basic Biomedical Sciences, Johns Hopkins School of Medicine
- David Mohr
- Johns Hopkins School of Medicine Genetic Resources Core Facility
- Kathryn R. Wagner
- Department of Neurology, Johns Hopkins School of Medicine
- Sergi Regot
- Department of Molecular Biology & Genetics, Johns Hopkins School of Medicine
- Richard M. Lovering
- Department of Orthopaedics, University of Maryland School of Medicine
- Peisong Gao
- Department of Medicine, Johns Hopkins School of Medicine
- Mario A. Bianchet
- Department of Neurology, Johns Hopkins School of Medicine
- Mark N. Wu
- Department of Neurology, Johns Hopkins School of Medicine
- Anthony Cammarato
- Department of Medicine, Johns Hopkins School of Medicine
- Martin F. Schneider
- Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine
- Gabriel S. Bever
- Department of Medicine, Johns Hopkins School of Medicine
- Mark E. Anderson
- Department of Medicine, Johns Hopkins School of Medicine
- DOI
- https://doi.org/10.1038/s41467-021-23549-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespan.
