Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

Han-jie Liu; Hui-min Hu; Guan-zhang Li; Ying Zhang; Fan Wu; Xiu Liu; Kuan-yu Wang; Chuan-bao Zhang; Tao Jiang; Tao Jiang; Tao Jiang; Tao Jiang; Tao Jiang

doi:10.3389/fcell.2020.00538

Frontiers in Cell and Developmental Biology (Jul 2020)

Ferroptosis-Related Gene Signature Predicts Glioma Cell Death and Glioma Patient Progression

Han-jie Liu,
Hui-min Hu,
Guan-zhang Li,
Ying Zhang,
Fan Wu,
Xiu Liu,
Kuan-yu Wang,
Chuan-bao Zhang,
Tao Jiang,
Tao Jiang,
Tao Jiang,
Tao Jiang,
Tao Jiang

Affiliations

Han-jie Liu: Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Hui-min Hu: Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Guan-zhang Li: Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Ying Zhang: Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Fan Wu: Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Xiu Liu: Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Kuan-yu Wang: Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Chuan-bao Zhang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Tao Jiang: Beijing Neurosurgical Institute and Beijing Tiantan Hospital of Capital Medical University, Beijing, China
Tao Jiang: Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
Tao Jiang: Center of Brain Tumor, Beijing Institute for Brain Disorders, Beijing, China
Tao Jiang: China National Clinical Research Center for Neurological Diseases, Beijing, China
Tao Jiang: Chinese Glioma Genome Atlas Network (CGGA) and Asian Glioma Genome Atlas Network (AGGA), Beijing, China

DOI: https://doi.org/10.3389/fcell.2020.00538
Journal volume & issue: Vol. 8

Abstract

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Glioma is a fatal brain tumor characterized by rapid proliferation and treatment resistance. Ferroptosis is a newly discovered programmed cell death and plays a crucial role in the occurrence and progression of tumors. In this study, we identified ferroptosis specific markers to reveal the relationship between ferroptosis-related genes and glioma by analyzing whole transcriptome data from Chinese Glioma Genome Atlas, The Cancer Genome Atlas dataset, GSE16011 dataset, and the Repository of Molecular Brain Neoplasia Data dataset. Nineteen ferroptosis-related genes with clinical and pathological features of glioma were identified as highly correlated. Functional assays in glioma cell lines indicated the association of ferroptosis with temozolomide resistance, autophagy, and glioma cell migration. Therefore, the identified ferroptosis-related genes were significantly correlated with glioma progression.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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