Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Ece Özelçi; Erik Mailand; Matthias Rüegg; Andrew C. Oates; Mahmut Selman Sakar

doi:10.1038/s41467-022-35632-4

Nature Communications (Dec 2022)

Deconstructing body axis morphogenesis in zebrafish embryos using robot-assisted tissue micromanipulation

Ece Özelçi,
Erik Mailand,
Matthias Rüegg,
Andrew C. Oates,
Mahmut Selman Sakar

Affiliations

Ece Özelçi: Institute of Mechanical Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Erik Mailand: Institute of Mechanical Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Matthias Rüegg: Institute of Mechanical Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)
Andrew C. Oates: Institute of Bioengineering, EPFL
Mahmut Selman Sakar: Institute of Mechanical Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL)

DOI: https://doi.org/10.1038/s41467-022-35632-4
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

Read online

Experimental microsurgery techniques are powerful for studying embryonic development but require highly trained operators to achieve reproducible results. Here they develop a high precision robotic micromanipulation platform to systematically perturb the physical structure of the developing zebrafish embryo, revealing key insights on the mechanics of body axis morphogenesis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal