Nature Communications (Dec 2017)
Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
- Guizhi Zhu,
- Geoffrey M. Lynn,
- Orit Jacobson,
- Kai Chen,
- Yi Liu,
- Huimin Zhang,
- Ying Ma,
- Fuwu Zhang,
- Rui Tian,
- Qianqian Ni,
- Siyuan Cheng,
- Zhantong Wang,
- Nan Lu,
- Bryant C. Yung,
- Zhe Wang,
- Lixin Lang,
- Xiao Fu,
- Albert Jin,
- Ido D. Weiss,
- Harshad Vishwasrao,
- Gang Niu,
- Hari Shroff,
- Dennis M. Klinman,
- Robert A. Seder,
- Xiaoyuan Chen
Affiliations
- Guizhi Zhu
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Geoffrey M. Lynn
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH
- Orit Jacobson
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Kai Chen
- Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California
- Yi Liu
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Huimin Zhang
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Ying Ma
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Fuwu Zhang
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Rui Tian
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Qianqian Ni
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Siyuan Cheng
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Zhantong Wang
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Nan Lu
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Bryant C. Yung
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Zhe Wang
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Lixin Lang
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Xiao Fu
- Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, NIH
- Albert Jin
- Laboratory of Cellular Imaging and Macromolecular Biophysics, NIBIB, NIH
- Ido D. Weiss
- Laboratory of Molecular Immunology, NIAID, NIH
- Harshad Vishwasrao
- Advanced Imaging and Microscopy Resource, National Institutes of Health
- Gang Niu
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- Hari Shroff
- Advanced Imaging and Microscopy Resource, National Institutes of Health
- Dennis M. Klinman
- Cancer and Inflammation Program, National Cancer Institute
- Robert A. Seder
- Vaccine Research Center, National Institute of Allergy and Infectious Diseases (NIAID), NIH
- Xiaoyuan Chen
- Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH)
- DOI
- https://doi.org/10.1038/s41467-017-02191-y
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Albumin conjugates can enhance drug delivery. Here, the authors repurpose albumin-binding Evans blue to develop nanovaccines that co-deliver adjuvants and tumor neoantigens to antigen-presenting cells in lymph nodes, resulting in potent and durable antitumour immunity in combination immunotherapy.
