Orbital: The Electronic Journal of Chemistry (Oct 2023)
The Green and Efficient One-pot Synthesis of Tetrahydrobenzo[b]pyran Derivatives
Abstract
Glutamic acid is used as an efficient organocatalyst for one-pot synthesis of tetrahydrobenzo [b]pyran via condensation of an aromatic aldehyde, dimedone and malononitrile in ethanol: water (1:4) as solvent at reflux temperature. The short reaction time, cleaner reaction, and easy workup make this protocol practical and economically attractive.
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