Acute Kidney Injury after Liver Transplantation

Abstract

Liver transplantation is the only curative treatment for terminal liver failure. Advances in immunosuppressive therapy and improvements in surgical techniques have improved patient survival in the post-transplant period. At the same time, however, the incidence of late complications is increasing, which has been contributed to by the broadening of the indication criteria in liver allocation. The most common complications include chronic kidney disease, the aetiology of which is multifactorial with a predominance of calcineurin inhibitor toxicity in the post-transplant period. The prevalence ranges from 30% to 90% depending on the definition used and the methodology used to measure renal function. Early detection of risk factors and early intervention lead to a significant improvement in the quality of life of recipients in the post-transplant period.

Keywords

• chronic kidney disease
• immunosuppression
• liver transplantation