Journal of Asthma and Allergy (Jun 2024)
Hematological, Biochemical, and Serum Levels of Allergic Mediators in Individuals with and without Allergic Rhinitis
Abstract
Miranda Selmonaj Rama,1 Bernard Tahirbegolli,2,3 Mentor Sopjani4 1Physiology with Immunology Department, Faculty of Medicine, University of Prishtina, Prishtina, Kosova; 2Management of Health Institutions and Services Department, Heimerer College, Prishtina, Kosova; 3Sports Medicine Department, National Sports Medicine Centre, Prishtina, Kosova; 4Department of Premedical Courses, Faculty of Medicine, University of Prishtina, Prishtina, KosovaCorrespondence: Mentor Sopjani, Department of Premedical Courses, Faculty of Medicine, University of Prishtina Str. Bulevardi i Dëshmorëve, p.n, Prishtina, 10000, Kosova, Tel +383 44 604 944, Email [email protected]: Allergic rhinitis (AR) is the most prevalent form of non-infectious rhinitis and is characterized by an immune response mediated by immunoglobulin E (IgE).Aim: This study aims to compare the levels of biochemical markers and other parameters in individuals with AR, non-allergic rhinitis(n-AR), allergic rhinitis accompanied by symptoms of the lower respiratory tract(AR-SLRT), and healthy controls.Study Design: Case control study.Methods: Blood samples from the three study groups, AR (n = 22), n-AR (n=20), AR-SLRT group (n = 21), and the control group (n = 18), were analyzed to ascertain the levels of total IgE, specific IgE, periostin, pendrin, vitamin D, thyroid-stimulating hormone (TSH), free triiodothyronine (Ft3), free thyroxine (Ft4), anti-thyroid peroxidase (TPO), and eosinophilic cationic protein (ECP), as well as the leukocyte formula and hemogram.Results: The AR and n-AR groups had significantly higher hematocrit values in comparison to the control group(p 0.05).Conclusion: All the investigated groups did not differ in ECP, periostin, pendrin, Ft3, Ft4, TSH, anti-TPO, or vitamin D parameters. The groups with positive AR and AR-SLRT had higher eosinophil counts than the control group. The group with AR-SLRT had higher total IgE concentrations than the other groups.Keywords: allergic rhinitis, allergic parameters, IgE, serum, allergic mediators
