Nature Communications (Jun 2018)
Late-life targeting of the IGF-1 receptor improves healthspan and lifespan in female mice
- Kai Mao,
- Gabriela Farias Quipildor,
- Tahmineh Tabrizian,
- Ardijana Novaj,
- Fangxia Guan,
- Ryan O. Walters,
- Fabien Delahaye,
- Gene B. Hubbard,
- Yuji Ikeno,
- Keisuke Ejima,
- Peng Li,
- David B. Allison,
- Hossein Salimi-Moosavi,
- Pedro J. Beltran,
- Pinchas Cohen,
- Nir Barzilai,
- Derek M. Huffman
Affiliations
- Kai Mao
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- Gabriela Farias Quipildor
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- Tahmineh Tabrizian
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- Ardijana Novaj
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- Fangxia Guan
- Department of Medicine, Albert Einstein College of Medicine
- Ryan O. Walters
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- Fabien Delahaye
- Department of Genetics, Albert Einstein College of Medicine
- Gene B. Hubbard
- Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio
- Yuji Ikeno
- Barshop Institute for Longevity and Aging Studies and Department of Pathology, University of Texas Health Science Center at San Antonio
- Keisuke Ejima
- School of Health Professions, The University of Alabama at Birmingham
- Peng Li
- School of Public Health, The University of Alabama at Birmingham
- David B. Allison
- School of Health Professions, The University of Alabama at Birmingham
- Hossein Salimi-Moosavi
- Department of Pharmacokinetics and Drug Metabolism, Amgen Inc.
- Pedro J. Beltran
- Oncology Research, Amgen Inc.
- Pinchas Cohen
- Davis School of Gerontology, University of Southern California
- Nir Barzilai
- Department of Medicine, Albert Einstein College of Medicine
- Derek M. Huffman
- Department of Molecular Pharmacology, Albert Einstein College of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-04805-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 12
Abstract
Reduced IGF-1 signaling increases longevity in many organisms. Here, Mao et al. show that administration of an anti-IGF-1R antibody is well tolerated and delays aging in female mice; importantly, late-life targeting is sufficient to achieve the beneficial effects.
