Nature Communications (Jun 2018)
Semen inhibits Zika virus infection of cells and tissues from the anogenital region
- Janis A. Müller,
- Mirja Harms,
- Franziska Krüger,
- Rüdiger Groß,
- Simone Joas,
- Manuel Hayn,
- Andrea N. Dietz,
- Sina Lippold,
- Jens von Einem,
- Axel Schubert,
- Manuela Michel,
- Benjamin Mayer,
- Mirko Cortese,
- Karen S. Jang,
- Nathallie Sandi-Monroy,
- Miriam Deniz,
- Florian Ebner,
- Olli Vapalahti,
- Markus Otto,
- Ralf Bartenschlager,
- Jean-Philippe Herbeuval,
- Jonas Schmidt-Chanasit,
- Nadia R. Roan,
- Jan Münch
Affiliations
- Janis A. Müller
- Institute of Molecular Virology, Ulm University Medical Center
- Mirja Harms
- Institute of Molecular Virology, Ulm University Medical Center
- Franziska Krüger
- Institute of Molecular Virology, Ulm University Medical Center
- Rüdiger Groß
- Institute of Molecular Virology, Ulm University Medical Center
- Simone Joas
- Institute of Molecular Virology, Ulm University Medical Center
- Manuel Hayn
- Institute of Molecular Virology, Ulm University Medical Center
- Andrea N. Dietz
- Institute of Virology, Ulm University Medical Center
- Sina Lippold
- Institute of Virology, Ulm University Medical Center
- Jens von Einem
- Institute of Virology, Ulm University Medical Center
- Axel Schubert
- Institute of Virology, Ulm University Medical Center
- Manuela Michel
- Institute of Virology, Ulm University Medical Center
- Benjamin Mayer
- Institute of Epidemiology and Medical Biometry, Ulm University
- Mirko Cortese
- Department of Infectious Diseases, Molecular Virology, Medical Faculty, Heidelberg University
- Karen S. Jang
- Gladstone Institute of Virology and Immunology
- Nathallie Sandi-Monroy
- Institute of Molecular Virology, Ulm University Medical Center
- Miriam Deniz
- Klinik für Frauenheilkunde und Geburtshilfe, Ulm University Medical Center
- Florian Ebner
- Klinik für Frauenheilkunde und Geburtshilfe, Ulm University Medical Center
- Olli Vapalahti
- Department of Virology and Immunology, University of Helsinki and Helsinki University Hospital
- Markus Otto
- Department of Neurology, Ulm University
- Ralf Bartenschlager
- Department of Infectious Diseases, Molecular Virology, Medical Faculty, Heidelberg University
- Jean-Philippe Herbeuval
- Chemistry, Biology, Modeling and Immunotherapy (CBMIT), CNRS, UMR8601, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, CICB Paris
- Jonas Schmidt-Chanasit
- Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Centre for Arbovirus and Hemorrhagic Fever Reference and Research
- Nadia R. Roan
- Gladstone Institute of Virology and Immunology
- Jan Münch
- Institute of Molecular Virology, Ulm University Medical Center
- DOI
- https://doi.org/10.1038/s41467-018-04442-y
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Semen from Zika virus infected individuals can contain high viral loads and can result in sexual transmission. Here, Müller et al. show that semen, and particularly seminal preparations containing extracellular vesicles, inhibit infection of Zika and other flaviviruses.
