The role of GPR56/ADGRG1 in health and disease

Abhishek Kumar Singh; Hsi-Hsien Lin

Biomedical Journal (Oct 2021)

The role of GPR56/ADGRG1 in health and disease

Abhishek Kumar Singh,
Hsi-Hsien Lin

Affiliations

Abhishek Kumar Singh: Department of Biological Sciences, Indian Institute of Science Education and Research, Mohali, India
Hsi-Hsien Lin: Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Division of Rheumatology, Allergy and Immunology, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Corresponding author. Department of Microbiology and Immunology, College of Medicine, Chang Gung University, 259, Wenhua 1st Rd., Gueishan, Taoyuan, 333 Taiwan.

Journal volume & issue: Vol. 44, no. 5
pp. 534 – 547

Abstract

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GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell generation. By contrast, aberrant expression or deregulated functions of GPR56 have been implicated in diverse pathological processes, including bilateral frontoparietal polymicrogyria, depression, and tumorigenesis. In this review article, we summarize and discuss the current understandings of the role of GPR56 in health and disease.

Published in Biomedical Journal

ISSN: 2319-4170 (Print); 2320-2890 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General); Science: Biology (General)
Website: https://www.sciencedirect.com/journal/biomedical-journal

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