Nature Communications (Jul 2016)

Common variants upstream of KDR encoding VEGFR2 and in TTC39B associate with endometriosis

  • Valgerdur Steinthorsdottir,
  • Gudmar Thorleifsson,
  • Kristrun Aradottir,
  • Bjarke Feenstra,
  • Asgeir Sigurdsson,
  • Lilja Stefansdottir,
  • Anna M. Kristinsdottir,
  • Florian Zink,
  • Gisli H. Halldorsson,
  • Nete Munk Nielsen,
  • Frank Geller,
  • Mads Melbye,
  • Daniel F. Gudbjartsson,
  • Reynir T. Geirsson,
  • Unnur Thorsteinsdottir,
  • Kari Stefansson

DOI
https://doi.org/10.1038/ncomms12350
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 6

Abstract

Read online

Endometriosis is a common gynaecological disease but the underlying pathogenesis is poorly understood, however there is a strong familial component. Here the authors conduct a genome wide association study and identify a novel susceptibility locus that correlates with disease severity.