The Potential of Sky Fruit as an Anti-Aging and Wound Healing Cosmeceutical Agent
Camille Keisha Mahendra,
Loh Teng Hern Tan,
Cayvern Kishen Mahendra,
Hooi-Leng Ser,
Priyia Pusparajah,
Thet Thet Htar,
Lay-Hong Chuah,
Wei Hsum Yap,
Siah Ying Tang,
Long Chiau Ming,
Yoon-Yen Yow,
Bey Hing Goh
Affiliations
Camille Keisha Mahendra
Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Loh Teng Hern Tan
Clinical School Johor Bahru, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Johor Bahru 80100, Johor, Malaysia
Cayvern Kishen Mahendra
Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Hooi-Leng Ser
Novel Bacteria and Drug Discovery Research Group, Microbiome and Bioresource Research Strength Jeffrey Cheah School of Medicine and Health Sciences, Monash University, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Priyia Pusparajah
Medical Health and Translational Research Group, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Thet Thet Htar
Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Lay-Hong Chuah
Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Wei Hsum Yap
School of Biosciences, Taylor’s University, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Siah Ying Tang
Chemical Engineering Discipline, School of Engineering, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Long Chiau Ming
Pengiran Anak Puteri Rashidah Sa’adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong, Bandar Seri Begawan BE1410, Brunei
Yoon-Yen Yow
Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
Bey Hing Goh
Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway, Subang Jaya 47500, Selangor Darul Ehsan, Malaysia
There are many extrinsic factors that can contribute to the premature aging of the skin. In recent years, the demand for natural cosmetic from the general population has noticeable grow. Therefore, this research aimed to investigate the bioproperties of sky fruit (Swietenia macrophylla) seed extract that could help to inhibit premature skin aging. Firstly, the extract and its fractions were tested on HaCaT cells for their wound healing properties. The presence of sky fruit’s extract and its fractions on scratch wound significantly improved cellular proliferation, migration, and closure of the wound. These effects were distinctly observed following the treatment with S. macrophylla hexane fraction (SMHF) and S. macrophylla water fraction (SMWF). Our continuous research study revealed that SMWF had antioxidant properties, which might be one of the factors contributing to its emerging wound healing properties because antioxidants are known to act as suppressors of the inflammatory pathway and aid the transition towards cell proliferation. In addition, all samples had critical wavelengths that indicated that they were able to absorb the whole UVB range and some parts of the UVA wavelength. This suggested that S. macrophylla might contain potential photoprotective bioactive compounds, which could be developed into anti-UVB photoprotective sunscreens. Thus, this warrants further studies focusing on isolation and identifications of the bioactive compounds responsible for both its photoprotective and wound healing properties. A deeper study on mechanisms of the pathways that were affected by these compounds should be conducted as well to better understand this natural product and develop it into a potential cosmeceutical ingredient.
