Evidence of Vaccine-related Reassortment of Rotavirus, Brazil, 2008–2010

Abstract

Analysis of 27 rotavirus strains from vaccinated and unvaccinated children revealed reassortment events in 3 strains: a gene derived from a vaccine; a gene acquired from a circulating strain; and reassortment between circulating strains. Data suggest that the widespread use of this monovalent rotavirus vaccine may introduce vaccine genes into circulating human rotaviruses or vice versa.

Keywords

• Rotarix
• vaccine
• G1P[8] strains
• phylogenetic analysis
• reassortment
• rotavirus