Respiratory Medicine Case Reports (Jan 2020)

Rechallenge of voriconazole successfully tolerated after hepatic toxicity

  • O. Narumoto,
  • J. Suzuki,
  • K. Takeda,
  • A. Tamura,
  • H. Nagai,
  • H. Matsui

Journal volume & issue
Vol. 31
p. 101191

Abstract

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Infections caused by Aspergillus species are often life-threatening. Drugs effective for Aspergillus infection are limited. Voriconazole is one of the most important drugs, however, considerable portion of patients experience liver toxicity and have to stop the drug administration. We frequently experience liver toxicity even though the serum concentration of voriconazole is within the target range. Historically, in some life-threatening situations like tuberculosis, where a suitable alternative is unavailable, rechallenge has been attempted. However, there have been no report on the rechallenge of voriconazole. We report cases of successful re-administration of voriconazole after liver toxicity.

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