Pharmaciana (May 2014)

PENGEMBANGAN SENYAWA TURUNAN BENZALASETON SEBAGAI SENYAWA TABIR SURYA

  • Susy Yunita Prabawati,
  • A Wijayanto,
  • Aria Wirahadi

DOI
https://doi.org/10.12928/pharmaciana.v4i1.395
Journal volume & issue
Vol. 4, no. 1
pp. 31 – 38

Abstract

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The goal of this research was to synthesize benzalaceton derivative i.e. 4-dimethyl-aminodibenzalaceton to increase the potency as sunscreen agent. The synthesis was carried out through aldol condensation reaction with 4- dimetilamino-benzaldehida as a starting material and NaOH as catalyst at various reaction times i.e. 3 , 4 and 6 hours. The characterizations of the product was observed by melting point, FTIR and 1 H NMR spectrometers. The product was obtained as a yellowish orange solid with a melting point between 62-640 C. The activity assay as sunscreen agent showed that the 4 – dimethylamino-dibenzalaseton have a maximum wavelength at 340 nm, so its can be active as a sunscreen in the UV - A rays. The SPF value at 15 ppm was 17.409 with ultra protection type.

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