Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

Abstract

Cancer treatment: Targeting more than just the tumor Targeting a signal protein in the tumor microenvironment (TME), the tissues surrounding tumors, as well as in the tumor itself may lead to more effective cancer treatments. High levels of the signal protein FAK are associated with many tumors. A pro-tumor function of FAK has recently also been reported from the TME, which can strongly influence treatment outcome. Ssang-Taek Steve Lim at the University of South Alabama, Mobile, USA, and co-workers have reviewed the functions of FAK in tumors and the TME. They report that FAK increases development and permeability of blood vessels in the TME, feeding the tumor and permitting cancer cells to travel to other locations. FAK also protects tumors from the immune response and from chemotherapy. These results point the way to treatments potentially effective against many types of cancer.