pH-responsive gelatin polymer-coated silica-based mesoporous composites for the sustained-release of indomethacin
Bo Yu,
Ruiping Shi,
Chunlai Liu,
Zelong Liu,
Peihang Shen,
Jianglei Hu,
Fengwei Shi
Affiliations
Bo Yu
School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China; College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China
Ruiping Shi
School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China
Chunlai Liu
School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China
Zelong Liu
School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China
Peihang Shen
School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China
Jianglei Hu
School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China; Corresponding authors.
Fengwei Shi
School of Chemical Engineering & Advanced Institute of Materials Science, Changchun University of Technology, Changchun 130012, China; Corresponding authors.
This paper prepared drug-loaded mesoporous silica composites with a pH-responsive type. These composites were prepared by using three-dimensional caged silica (SBA-16) as the carrier, 3-aminopropyl trimethoxysilane (APTMS) as the silane coupling agent, and indomethacin (IMC) as the loaded drug, respectively. The drug-loaded precursor NH2-SBA-16@IMC was prepared by solution diffusion adsorption. Finally, the pH-responsive drug-loaded composites NH2-SBA-16@IMC@GA were synthesized by wrapping the NH2-SBA-16@IMC with a condensation polymer of gelatin and glutaraldehyde. The composition and structure of the drug-loaded composites were characterized by FT-IR, XRD, TG, SEM, TEM, and N2 adsorption-desorption. The in vitro simulated release performance of the drug-loaded composites was investigated at 37 °C under three pH conditions. The results show that the NH2-SBA-16@IMC@GA can be released in response to specific pH environment, which can effectively control the release speed of the indomethacin.
