Nature Communications (May 2021)
A sand fly salivary protein acts as a neutrophil chemoattractant
- Anderson B. Guimaraes-Costa,
- John P. Shannon,
- Ingrid Waclawiak,
- Jullyanna Oliveira,
- Claudio Meneses,
- Waldione de Castro,
- Xi Wen,
- Joseph Brzostowski,
- Tiago D. Serafim,
- John F. Andersen,
- Heather D. Hickman,
- Shaden Kamhawi,
- Jesus G. Valenzuela,
- Fabiano Oliveira
Affiliations
- Anderson B. Guimaraes-Costa
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- John P. Shannon
- Viral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Ingrid Waclawiak
- Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Universidade Federal do Rio de Janeiro
- Jullyanna Oliveira
- Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Universidade Federal do Rio de Janeiro
- Claudio Meneses
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Waldione de Castro
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Xi Wen
- Chemotaxis Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH
- Joseph Brzostowski
- Twinbrook Imaging Facility, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, NIH
- Tiago D. Serafim
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- John F. Andersen
- Vector Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Heather D. Hickman
- Viral Immunity and Pathogenesis Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Shaden Kamhawi
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Jesus G. Valenzuela
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Fabiano Oliveira
- Vector Molecular Biology Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- DOI
- https://doi.org/10.1038/s41467-021-23002-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Immune mimicry has been shown in chemokine like moieties from bacteria and viruses. Here, the authors characterise a sand fly salivary protein that induces neutrophil chemotaxis and explore its impact in a model of parasitic infection.
