Frontiers in Immunology (Oct 2024)
A guideline on biomarkers in the diagnosis and evaluation in axial spondyloarthritis
- Dong Liu,
- Ya Xie,
- Liudan Tu,
- Xianghui Wen,
- Xianghui Wen,
- Qing Lv,
- Budian Liu,
- Mingcan Yang,
- Xinyu Wu,
- Xuqi Zheng,
- Xiqing Luo,
- Liuzhong Zhou,
- Jialing Wu,
- Bin Liu,
- Kun Wang,
- Ou Jin,
- Xiaohong Wang,
- Jie Qin,
- Lijun Wu,
- Dongbao Zhao,
- Dongyi He,
- Shanzhi He,
- Wenhui Huang,
- Shanhui Ye,
- Huiqiong Zhou,
- Jinyu Wu,
- Yongfu Wang,
- Shengyun Liu,
- Zhenbin Li,
- Zhiming Tan,
- Chiduo Xu,
- Youlian Wang,
- Donghui Zheng,
- Feng Zhan,
- Changsong Lin,
- Ya Wen,
- Jiayun Wu,
- Shenghui Wen,
- Zetao Liao,
- Yan Shen,
- Kehu Yang,
- Jieruo Gu,
- Jieruo Gu
Affiliations
- Dong Liu
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Ya Xie
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Liudan Tu
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Xianghui Wen
- Department of Rheumatology, Shenzhen Longhua District Central Hospital, Shenzhen, China
- Xianghui Wen
- Shenzhen Longhua Institute of Immunology Transformation, Shenzhen, China
- Qing Lv
- Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China
- Budian Liu
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Mingcan Yang
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Xinyu Wu
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Xuqi Zheng
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Xiqing Luo
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Liuzhong Zhou
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Jialing Wu
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Bin Liu
- Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Kun Wang
- Department of Joint Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Ou Jin
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Xiaohong Wang
- Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Jie Qin
- Department of Radiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Lijun Wu
- Department of Rheumatology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumchi, China
- Dongbao Zhao
- Department of Rheumatology, Changhai Hospital, Shanghai, China
- Dongyi He
- 0Department of Rheumatology, Shanghai Guanghua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Shanzhi He
- 1Department of Rheumatology, Zhongshan City People’s Hospital, Zhongshan, China
- Wenhui Huang
- 2Department of Rheumatology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
- Shanhui Ye
- 3Department of Rheumatology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
- Huiqiong Zhou
- 4Department of Rheumatology, The Fourth Central Hospital Chinese PLA Medical School, Xi’an, China
- Jinyu Wu
- 5Department of Rheumatology, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, China
- Yongfu Wang
- 6Department of Rheumatology, The First Affiliated Hospital of Baotou Medical College, Baotou, China
- Shengyun Liu
- 7Department of Rheumatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
- Zhenbin Li
- 8Department of Rheumatology, Bethune International Peace Hospital, Shijiazhuang, China
- Zhiming Tan
- 9Department of Rheumatology, Huizhou Central Hospital, Huizhou, China
- Chiduo Xu
- 0Department of Rheumatology, The Second People‘s Hospital of Shenzhen City, Shenzhen, China
- Youlian Wang
- 1Department of Rheumatology, Jiangxi Province People’s Hospital, Nanchang, China
- Donghui Zheng
- 2Department of Rheumatology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China
- Feng Zhan
- 3Department of Nephropathy and Rheumatology, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, China
- Changsong Lin
- 4Department of Rheumatology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
- Ya Wen
- Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China
- Jiayun Wu
- Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China
- Shenghui Wen
- Department of Rheumatology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, China
- Zetao Liao
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Yan Shen
- 5National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Science and Peking Union Medical College, Tsinghua University, Beijing, China
- Kehu Yang
- 6Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China
- Jieruo Gu
- Department of Rheumatology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
- Jieruo Gu
- Shenzhen Longhua Institute of Immunology Transformation, Shenzhen, China
- DOI
- https://doi.org/10.3389/fimmu.2024.1394148
- Journal volume & issue
-
Vol. 15
Abstract
ObjectiveTo develop a guideline for selecting biomarkers in the diagnosis and assessment in patients with axial spondyloarthritis (axSpA).MethodA joint effort was carried out by the core team, the literature review team and the multidisciplinary voting panel to formulate recommendations regarding biomarkers in axSpA, using an evidence-based and consensus-based strategy. Certainty of evidence and strength of recommendation were determined, and levels of agreement within the voting panel were calculated.ResultsA total of 20 recommendations were formulated in this guideline, with levels of agreement ranging from 6.48 to 9.71. The two strong recommendations, HLA-B27 testing in patients suspected of axSpA and regular-interval monitoring of CRP/ESR represent the status quo of axSpA evaluation, while the 13 conditional recommendations represent the promising biomarkers with clinical utility in diagnosis, disease activity assessment, prediction of radiographic progression and therapeutic responses. This guideline does not dictate clinical choices of tests on axSpA, and decisions should be made based on comprehensive consideration of costs, accessibility, patients’ values and willingness as well as the objective of testing in the local context.ConclusionThis guideline addresses the interpretation of the clinical significance of biomarkers in axSpA, and the biomarkers endorsed in this guideline composed a clinical toolkit for healthcare professionals to choose from.
Keywords
