BXD Recombinant Inbred Mice as a Model to Study Neurotoxicity
Airton C. Martins,
Caridad López-Granero,
Beatriz Ferrer,
Alexey A. Tinkov,
Anatoly V. Skalny,
Monica M. B. Paoliello,
Michael Aschner
Affiliations
Airton C. Martins
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Caridad López-Granero
Departamento de Psicología y Sociología, Campus Ciudad Escolar, Universidad de Zaragoza, 44003 Teruel, Spain
Beatriz Ferrer
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Alexey A. Tinkov
Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University, 119435 Moscow, Russia
Anatoly V. Skalny
World-Class Research Center “Digital Biodesign and Personalized Healthcare”, IM Sechenov First Moscow State Medical University (Sechenov University), 119435 Moscow, Russia
Monica M. B. Paoliello
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Michael Aschner
Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
BXD recombinant inbred (RI) lines represent a genetic reference population derived from a cross between C57BL/6J mice (B6) and DBA/2J mice (D2), which through meiotic recombination events possesses recombinant chromosomes containing B6 or D2 haplotype segments. The quantitative trait loci (QTLs) are the locations of segregating genetic polymorphisms and are fundamental to understanding genetic diversity in human disease susceptibility and severity. QTL mapping represents the typical approach for identifying naturally occurring polymorphisms that influence complex phenotypes. In this process, genotypic values at markers of known genomic locations are associated with phenotypic values measured in a segregating population. Indeed, BXD RI strains provide a powerful tool to study neurotoxicity induced by different substances. In this review, we describe the use of BXD RI lines to understand the underlying mechanisms of neurotoxicity in response to ethanol and cocaine, as well as metals and pesticide exposures.
