Brazilian Journal of Pharmaceutical Sciences (Oct 2021)

Chemical composition, larvicidal and cytotoxic activity of Annona salzmannii (Annonaceae) seed oil

  • Jane Cristina Lara Ribeiro,
  • Estevan Bruginski,
  • Tatiana Zuccolotto,
  • Alan Diego da Conceição Santos,
  • Larissa Mendes Bomfim,
  • Suellen Laila Andrade Rocha,
  • Andersson Barison,
  • Guilherme Sassaki,
  • Sócrates Cabral de Holanda Cavalcanti,
  • Emmanoel Vilaça Costa,
  • Milena Botelho Pereira Soares,
  • Daniel Pereira Bezerra,
  • Francinete Ramos Campos

DOI
https://doi.org/10.1590/s2175-97902020000418479
Journal volume & issue
Vol. 57

Abstract

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The seed oil of Annona salzmannii A. DC. was analyzed by GC-MS and 1H qNMR, revealing a mixture of unsaturated (80.5%) and saturated (18.7%) fatty acids. Linoleic (45.3%) and oleic (33.5%) acid were the major unsaturated fatty acids identified, while palmitic acid (14.3%) was the major saturated fatty acid. The larvicidal effects of A. salzmannii seed oil were evaluated against third-instar larvae of Aedes aegypti (Linn.). The oil exhibited moderate larvicidal activity, with a LC50 of 569.77 ppm (95% CI = 408.11 to 825.88 ppm). However, when the cytotoxic effects of the oil were evaluated, no expressive antiproliferative effects were observed in tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia), HL-60 (human promyelocytic leukemia), and non-tumor cell line PBMC (peripheral blood mononuclear cells), with IC50 values > 50 μg·mL-1. This is the first study to evaluate the chemical composition, larvicidal and cytotoxic activity of A. salzmannii seed oil.

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