T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

Meng Zhou; Faruk Sacirbegovic; Kai Zhao; Sarah Rosenberger; Warren D. Shlomchik

doi:10.1038/s41467-020-17991-y

Nature Communications (Aug 2020)

T cell exhaustion and a failure in antigen presentation drive resistance to the graft-versus-leukemia effect

Meng Zhou,
Faruk Sacirbegovic,
Kai Zhao,
Sarah Rosenberger,
Warren D. Shlomchik

Affiliations

Meng Zhou: Department of Medicine, University of Pittsburgh School of Medicine
Faruk Sacirbegovic: Department of Medicine, University of Pittsburgh School of Medicine
Kai Zhao: Department of Medicine, University of Pittsburgh School of Medicine
Sarah Rosenberger: Department of Medicine, University of Pittsburgh School of Medicine
Warren D. Shlomchik: Department of Medicine, University of Pittsburgh School of Medicine

DOI: https://doi.org/10.1038/s41467-020-17991-y
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 18

Abstract

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In hematopoietic stem cell transplants, T cells mediate graft-versus-leukemia (GVL), but GVL can fail leading to leukemia relapse. Here the authors use a mouse model in which T cells target the minor histocompatibility antigen H60 to show how this can occur, characterize the CD8+ T cell response and demonstrate how anti-CD40 antibody therapy improves GVL.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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