Sultan Qaboos University Medical Journal (Apr 2002)

Genotypes and Allele Frequencies of Angiotensin Converting Enzyme (ACE) Insertion/deletion polymorphism among Omanis

  • Ali T. Al-Hinai,
  • Mohammed O Hassan,
  • Mehmet Simsek,
  • Hameeda Al-Barwani,
  • Riad Bayoumi

Journal volume & issue
Vol. 4, no. 1
pp. 25 – 27

Abstract

Read online

Objective: To describe the angiotensin converting enzyme (ACE) genotype frequencies among Omani Arabs. Method: A polymerase chain reaction (PCR) test, based on separation of different size DNA fragments, was developed to test the presence or absence (polymorphism) of a small DNA deletion in the ACE gene. The subjects were 124 Omani Arab students of Sultan Qaboos University, Muscat. Results: The frequency of the I allele was 0.29, while that of the D allele was 0.71. The gene frequency distribution did not deviate from Hardy-Weinberg equilibrium. Conclusions: The frequency of D allele among Omanis is similar to that among other Arabs and Africans, but differs significantly from that among the Japanese and Chinese.

Keywords