Фармакокинетика и Фармакодинамика (Mar 2016)
Experimental study of chronic toxicity and allergenic properties of the drug afobazol
Abstract
The study of chronic toxicity injection form afobazol with daily intravenous administration for 2 weeks old female and male rats in doses of 0,1; 1; 5 and 50 mg/kg, female and male rabbits at doses of 0,1; 1 and 10 mg/kg. A detailed clinical and laboratory examination did not reveal any toxic effects of the drug in doses of 0,1 - 5 mg/kg. Afobazol when administered intravenously in doses of 10 mg/kg for rabbits and 50 mg/kg in rats induced clonic convulsions, and intermittent loss of coordination of movement, and at the same dosage segment PQ increased in female rats. Afobazol 10 and 50 mg/kg increased levels of glucose and total protein in laboratory animals and decreased the content of urea in blood serum of rats. Investigation showed allergenic properties afobazol in doses of 5 and 50 mg/kg did not cause allergic reactions of immediate and delayed type reactions and pseudoallergic. The slight increase in allergic reactions to foreign protein when administered afobazol indicates the possibility of individual sensitivity in people with protein sensitization.
