The Intercalation of CORM-2 with Pharmaceutical Clay Montmorillonite (MMT) Aids for Therapeutic Carbon Monoxide Release

Muhammad Faizan; Kifayat  Ullah Khan Niazi; Niaz Muhammad; Yongxia Hu; Yanyan Wang; Dezhi Lin; Yuanyuan Liu; Weiqiang Zhang; Ziwei Gao

doi:10.3390/ijms20143453

International Journal of Molecular Sciences (Jul 2019)

The Intercalation of CORM-2 with Pharmaceutical Clay Montmorillonite (MMT) Aids for Therapeutic Carbon Monoxide Release

Muhammad Faizan,
Kifayat Ullah Khan Niazi,
Niaz Muhammad,
Yongxia Hu,
Yanyan Wang,
Dezhi Lin,
Yuanyuan Liu,
Weiqiang Zhang,
Ziwei Gao

Affiliations

Muhammad Faizan: Key Laboratory of Applied Surface and Colloid Chemistry MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Kifayat Ullah Khan Niazi: School of Materials Science and Engineering, Xi’an Jiaotong University, Xi’an 710049, China
Niaz Muhammad: Department of Biochemistry, College of Life Sciences, Shaanxi Normal University, Xi’an 710062, China
Yongxia Hu: Key Laboratory of Applied Surface and Colloid Chemistry MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Yanyan Wang: Key Laboratory of Applied Surface and Colloid Chemistry MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Dezhi Lin: Key Laboratory of Applied Surface and Colloid Chemistry MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Yuanyuan Liu: Key Laboratory of Applied Surface and Colloid Chemistry MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Weiqiang Zhang: Key Laboratory of Applied Surface and Colloid Chemistry MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China
Ziwei Gao: Key Laboratory of Applied Surface and Colloid Chemistry MOE, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, China

DOI: https://doi.org/10.3390/ijms20143453
Journal volume & issue: Vol. 20, no. 14
p. 3453

Abstract

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The pharmaceutical clay montmorillonite (MMT) is, for the first time, explored as a carbon monoxide-releasing material (CORMat). MMT consists of silicate double layered structure; its exfoliation feature intercalate the CORM-2 [RuCl(μ-Cl)(CO)3]2 inside the layers to suppress the toxicity of organometallic segment. The infrared spectroscopy (IR) confirmed the existence of ruthenium coordinated carbonyl ligand in MMT layers. The energy-dispersive X-ray spectroscopy (EDX) analysis showed that ruthenium element in this material was about 5%. The scanning electron microscopy (SEM) and transmission electron microscope (TEM) images showed that the layer-structure of MMT has been maintained after loading the ruthenium carbonyl segment. Moreover, the layers have been stretched out, which was confirmed by X-ray diffraction (XRD) analysis. Thermogravimetric (TG) curves with huge weight loss around 100−200 °C were attributed to the CO hot-release of ruthenium carbonyl as well as the loss of the adsorbed solvent molecules and the water molecules between the layers. The CO-liberating properties have been assessed through myoglobin assay. The horse myoglobin test showed that the material could be hydrolyzed to slowly release carbon monoxide in physiological environments. The half-life of CO release was much longer than that of CORM-3, and it has an excellent environmental tolerance and slow release effect.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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