Immune Microenvironment: New Insight for Familial Adenomatous Polyposis

Jun Yang; Zhengqi Wen; Wenliang Li; Xianghua Sun; Junrui Ma; Xueke She; Hongbin Zhang; Changling Tu; Guoqiang Wang; Depei Huang; Xudong Shen; Jian Dong; Hushan Zhang

doi:10.3389/fonc.2021.570241

Frontiers in Oncology (Feb 2021)

Immune Microenvironment: New Insight for Familial Adenomatous Polyposis

Jun Yang,
Zhengqi Wen,
Wenliang Li,
Xianghua Sun,
Junrui Ma,
Xueke She,
Hongbin Zhang,
Changling Tu,
Guoqiang Wang,
Depei Huang,
Xudong Shen,
Jian Dong,
Hushan Zhang

Affiliations

Jun Yang: Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, China
Zhengqi Wen: Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, China
Wenliang Li: Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, China
Xianghua Sun: Department of Cadre Recuperation, The First Affiliated Hospital of Kunming Medical University, Kunming, China
Junrui Ma: Department of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Xueke She: The Medical Department, 3D Medicines Inc., Shanghai, China
Hongbin Zhang: Department of Oncology, First Affiliated Hospital of Kunming Medical University, Kunming, China
Changling Tu: Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Yunan Cancer Hospital, Kunming, China
Guoqiang Wang: The Medical Department, 3D Medicines Inc., Shanghai, China
Depei Huang: The Medical Department, 3D Medicines Inc., Shanghai, China
Xudong Shen: The Medical Department, 3D Medicines Inc., Shanghai, China
Jian Dong: Department of Medical Oncology, The Third Affiliated Hospital of Kunming Medical University, Yunan Cancer Hospital, Kunming, China
Hushan Zhang: The Medical Department, 3D Medicines Inc., Shanghai, China

DOI: https://doi.org/10.3389/fonc.2021.570241
Journal volume & issue: Vol. 11

Abstract

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Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fibroids. Therefore, it is necessary to further expand the understanding of FAP and develop new treatments for FAP. The immune microenvironment including immune cells and cytokines, plays an important role in FAP and the progression of FAP to adenocarcinoma, thus it may be a promising treatment for FAP. In the current review, we summarized the recent progress in the immune microenvironment of FAP.

Published in Frontiers in Oncology

ISSN: 2234-943X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.frontiersin.org/journals/oncology/

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Abstract

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