Nature Communications (Jun 2018)
Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E
- Argel Aguilar-Valles,
- Nabila Haji,
- Danilo De Gregorio,
- Edna Matta-Camacho,
- Mohammad J. Eslamizade,
- Jelena Popic,
- Vijendra Sharma,
- Ruifeng Cao,
- Christoph Rummel,
- Arnaud Tanti,
- Shane Wiebe,
- Nicolas Nuñez,
- Stefano Comai,
- Robert Nadon,
- Giamal Luheshi,
- Naguib Mechawar,
- Gustavo Turecki,
- Jean-Claude Lacaille,
- Gabriella Gobbi,
- Nahum Sonenberg
Affiliations
- Argel Aguilar-Valles
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- Nabila Haji
- Department of Neurosciences and Groupe de Recherche sur le Système Nerveux Central (GRSNC), Université de Montréal
- Danilo De Gregorio
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- Edna Matta-Camacho
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- Mohammad J. Eslamizade
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- Jelena Popic
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- Vijendra Sharma
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- Ruifeng Cao
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- Christoph Rummel
- Institute of Veterinary Physiology and Biochemistry, Justus-Liebig-University Giessen
- Arnaud Tanti
- Department of Psychiatry, McGill University
- Shane Wiebe
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- Nicolas Nuñez
- Department of Psychiatry, McGill University
- Stefano Comai
- Department of Psychiatry, McGill University
- Robert Nadon
- Department of Human Genetics, McGill University and Genome Quebec Innovation Centre
- Giamal Luheshi
- Department of Psychiatry, McGill University
- Naguib Mechawar
- Department of Psychiatry, McGill University
- Gustavo Turecki
- Department of Psychiatry, McGill University
- Jean-Claude Lacaille
- Department of Neurosciences and Groupe de Recherche sur le Système Nerveux Central (GRSNC), Université de Montréal
- Gabriella Gobbi
- Department of Psychiatry, McGill University
- Nahum Sonenberg
- Department of Biochemistry and Goodman Cancer Centre, McGill University
- DOI
- https://doi.org/10.1038/s41467-018-04883-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 14
Abstract
Translation of mRNA contributes to neuronal function and complex behaviours, and inflammation is thought to contribute to depression. Here the authors show that mice lacking phosphorylation sites in eIF4E (eukaryotic initiation factor 4E) display anxiety- and depression-like behaviour and decreased IkBα expression; furthermore TNFα delivery to the medial prefrontal cortex induces depression-like behaviour and deficits in serotonergic transmission.
