Nature Communications (Mar 2020)

A signaling hub of insulin receptor, dystrophin glycoprotein complex and plakoglobin regulates muscle size

  • Yara Eid Mutlak,
  • Dina Aweida,
  • Alexandra Volodin,
  • Bar Ayalon,
  • Nitsan Dahan,
  • Anna Parnis,
  • Shenhav Cohen

DOI
https://doi.org/10.1038/s41467-020-14895-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Insulin receptor signaling governs central physiological functions related to cell growth and metabolism. Here the authors use protein complex purification and super-resolution microscopy to show that insulin receptor activity requires association with dystrophin glycoprotein complex and plakoglobin.