Aberrant regional homogeneity in post-traumatic stress disorder after traffic accident: A resting-state functional MRI study

Shishun Fu; Xiaofen Ma; Changhong Li; Tianyue Wang; Chao Li; Zhigang Bai; Kelei Hua; Yi Yin; Yunfan Wu; Kanghui Yu; Mengchen Liu; Qiying Ke; Junzhang Tian; Guihua Jiang

NeuroImage: Clinical (Jan 2019)

Aberrant regional homogeneity in post-traumatic stress disorder after traffic accident: A resting-state functional MRI study

Shishun Fu,
Xiaofen Ma,
Changhong Li,
Tianyue Wang,
Chao Li,
Zhigang Bai,
Kelei Hua,
Yi Yin,
Yunfan Wu,
Kanghui Yu,
Mengchen Liu,
Qiying Ke,
Junzhang Tian,
Guihua Jiang

Affiliations

Shishun Fu: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China
Xiaofen Ma: The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China
Changhong Li: The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China
Tianyue Wang: The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China
Chao Li: The First Affiliated Hospital of China Medical University, People's Republic of China
Zhigang Bai: The Affiliated Hospital of Inner Mongolia Medical University, People's Republic of China
Kelei Hua: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China; The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China
Yi Yin: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China; The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China
Yunfan Wu: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China; The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China
Kanghui Yu: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China; The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China
Mengchen Liu: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China
Qiying Ke: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China
Junzhang Tian: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China; The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China; Corresponding author at: Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou 510317, People's Republic of China.
Guihua Jiang: The Second School of Clinical Medicine, Southern Medical University, People's Republic of China; The Department of Medical Imaging Guangdong Second Provincial General Hospital, Southern Medical University, People's Republic of China; Corresponding author at: Guangdong Second Provincial General Hospital, Southern Medical University, Guangzhou 510317, People's Republic of China.

Journal volume & issue: Vol. 24

Abstract

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Objectives: The present study explored the changes in spontaneous regional activity in post-traumatic stress disorder (PTSD) patients, who experienced severe traffic accidents. Methods: 20 drug-naive PTSD patients and 18 healthy control subjects were imaged using resting-state functional magnetic resonance imaging (rs-fMRI) and analyzed by the algorithm of regional homogeneity (ReHo). Results: Compared to the healthy control group, the PTSD group showed decreased ReHo values in the right angular gyrus. In addition, a negative correlation was found between the activity level of the angular gyrus and the CAPS score. Conclusion: The dysfunctions were found in the memory- and emotion-related areas, suggested a possible mechanism of memory dysregulation that might be related to the intrusive memory symptoms of PTSD. These results provided imaging evidence that might provide an in-depth understanding of the intrinsic functional architecture of PTSD. Keywords: PTSD, Angular gyrus, fMRI, Traffic accidents

Published in NeuroImage: Clinical

ISSN: 2213-1582 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General): Computer applications to medicine. Medical informatics; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: http://www.journals.elsevier.com/neuroimage-clinical/

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