Nature Communications (Apr 2018)
Fetal demise and failed antibody therapy during Zika virus infection of pregnant macaques
- Diogo M. Magnani,
- Thomas F. Rogers,
- Nicholas J. Maness,
- Nathan D. Grubaugh,
- Nathan Beutler,
- Varian K. Bailey,
- Lucas Gonzalez-Nieto,
- Martin J. Gutman,
- Núria Pedreño-Lopez,
- Jaclyn M. Kwal,
- Michael J. Ricciardi,
- Tereance A. Myers,
- Justin G. Julander,
- Rudolf P. Bohm,
- Margaret H. Gilbert,
- Faith Schiro,
- Pyone P. Aye,
- Robert V. Blair,
- Mauricio A. Martins,
- Kathrine P. Falkenstein,
- Amitinder Kaur,
- Christine L. Curry,
- Esper G. Kallas,
- Ronald C. Desrosiers,
- Pascal J. Goldschmidt-Clermont,
- Stephen S. Whitehead,
- Kristian G. Andersen,
- Myrna C. Bonaldo,
- Andrew A. Lackner,
- Antonito T. Panganiban,
- Dennis R. Burton,
- David I. Watkins
Affiliations
- Diogo M. Magnani
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Thomas F. Rogers
- Department of Immunology and Microbiology, The Scripps Research Institute
- Nicholas J. Maness
- Tulane National Primate Research Center
- Nathan D. Grubaugh
- Department of Immunology and Microbiology, The Scripps Research Institute
- Nathan Beutler
- Department of Immunology and Microbiology, The Scripps Research Institute
- Varian K. Bailey
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Lucas Gonzalez-Nieto
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Martin J. Gutman
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Núria Pedreño-Lopez
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Jaclyn M. Kwal
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Michael J. Ricciardi
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Tereance A. Myers
- Tulane National Primate Research Center
- Justin G. Julander
- Institute for Antiviral Research, Utah State University
- Rudolf P. Bohm
- Tulane National Primate Research Center
- Margaret H. Gilbert
- Tulane National Primate Research Center
- Faith Schiro
- Tulane National Primate Research Center
- Pyone P. Aye
- Tulane National Primate Research Center
- Robert V. Blair
- Tulane National Primate Research Center
- Mauricio A. Martins
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Kathrine P. Falkenstein
- Tulane National Primate Research Center
- Amitinder Kaur
- Tulane National Primate Research Center
- Christine L. Curry
- Department of Obstetrics and Gynecology, University of Miami Leonard M. Miller School of Medicine
- Esper G. Kallas
- Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo
- Ronald C. Desrosiers
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- Pascal J. Goldschmidt-Clermont
- Department of Medicine, University of Miami Leonard M. Miller School of Medicine
- Stephen S. Whitehead
- Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health
- Kristian G. Andersen
- Department of Immunology and Microbiology, The Scripps Research Institute
- Myrna C. Bonaldo
- Laboratório de Biologia Molecular de Flavivírus, Instituto Oswaldo Cruz, Fiocruz
- Andrew A. Lackner
- Tulane National Primate Research Center
- Antonito T. Panganiban
- Tulane National Primate Research Center
- Dennis R. Burton
- Department of Immunology and Microbiology, The Scripps Research Institute
- David I. Watkins
- Department of Pathology, University of Miami Leonard M. Miller School of Medicine
- DOI
- https://doi.org/10.1038/s41467-018-04056-4
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 8
Abstract
Zika virus (ZIKV) infection in pregnant women has been associated with fetal developmental defects. Here, the authors show that a Brazilian ZIKV isolate causes fetal demise in non-human primates and that antibody treatment at time of peak viremia is insufficient to clear ZIKV replication from amniotic fluid.
