The effects of time restricted feeding on age-related changes in the mouse retina

Cade A. Huston; Madison Milan; Michaela L. Vance; Marisa A. Bickel; Lauren R. Miller; Sharon Negri; Clara Hibbs; Hannah Vaden; Lindsay Hayes; Anna Csiszar; Zoltan Ungvari; Andriy Yabluchanskiy; Stefano Tarantini; Shannon M. Conley

Experimental Gerontology (Sep 2024)

The effects of time restricted feeding on age-related changes in the mouse retina

Cade A. Huston,
Madison Milan,
Michaela L. Vance,
Marisa A. Bickel,
Lauren R. Miller,
Sharon Negri,
Clara Hibbs,
Hannah Vaden,
Lindsay Hayes,
Anna Csiszar,
Zoltan Ungvari,
Andriy Yabluchanskiy,
Stefano Tarantini,
Shannon M. Conley

Affiliations

Cade A. Huston: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Madison Milan: Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Neuroscience and Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Michaela L. Vance: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Marisa A. Bickel: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Lauren R. Miller: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Sharon Negri: Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Clara Hibbs: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Hannah Vaden: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Lindsay Hayes: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Anna Csiszar: Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Neuroscience and Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine, Department of Public Health, Semmelweis University, Budapest, Hungary
Zoltan Ungvari: Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Neuroscience and Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine, Department of Public Health, Semmelweis University, Budapest, Hungary
Andriy Yabluchanskiy: Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Neuroscience and Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
Stefano Tarantini: Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Department of Neuroscience and Neurosurgery, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Hudson College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Correspondence to: S. Tarantini, Stephenson Cancer Center, Department of Neurosurgery, Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, 975 NE 10th street, Oklahoma City, OK 73104, USA.
Shannon M. Conley: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Center for Geroscience and Healthy Brain Aging, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA; Correspondence to: S. Conley, University of Oklahoma Health Sciences Center, Department of Cell Biology, 940 Stanton L. Young Blvd., BMSB 553, Oklahoma City, OK 73104, USA.

Journal volume & issue: Vol. 194
p. 112510

Abstract

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Dietary modifications such as caloric restriction (CR) and intermittent fasting (IF) have gained popularity due to their proven health benefits in aged populations. In time restricted feeding (TRF), a form of intermittent fasting, the amount of time for food intake is regulated without restricting the caloric intake. TRF is beneficial for the central nervous system to support brain health in the context of aging. Therefore, we here ask whether TRF also exerts beneficial effects in the aged retina. We compared aged mice (24 months) on a TRF paradigm (access to food for six hours per day) for either 6 or 12 months against young control mice (8 months) and aged control mice on an ad libitum diet. We examined changes in the retina at the functional (electroretinography), structural (histology and fluorescein angiograms) and molecular (gene expression) level. TRF treatment showed amelioration of age-related reductions in both scotopic and photopic b-wave amplitudes suggesting benefits for retinal interneuron signaling. TRF did not affect age-related signs of retinal inflammation or microglial activation at either the molecular or histological level. Our data indicate that TRF helps preserve some aspects of retinal function that are decreased with aging, adding to our understanding of the health benefits that altered feeding patterns may confer.

Published in Experimental Gerontology

ISSN: 1873-6815 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine; Science: Biology (General)
Website: https://www.sciencedirect.com/journal/experimental-gerontology

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