Nature Communications (May 2018)

PCGF5 is required for neural differentiation of embryonic stem cells

  • Mingze Yao,
  • Xueke Zhou,
  • Jiajian Zhou,
  • Shixin Gong,
  • Gongcheng Hu,
  • Jiao Li,
  • Kaimeng Huang,
  • Ping Lai,
  • Guang Shi,
  • Andrew P. Hutchins,
  • Hao Sun,
  • Huating Wang,
  • Hongjie Yao

DOI
https://doi.org/10.1038/s41467-018-03781-0
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Polycomb-group proteins are key regulators of transcriptional programs that maintain cell identity. Here the authors provide evidence that PCGF5, a subunit of Polycomb Repressor Complex 1, is important for the differentiation of mouse embryonic stem cells towards a neural cell fate.