Effectiveness of potassium iodide in the treatment of GERD patients in combination with iodine deficiency states

Abstract

GERD and iodine deficiency conditions are not only limited by similar clinical symptoms. They influence on each other by regulatory kinetic mechanisms of upper gastrointestinal tract. Aim. We examined 40 patients with GERD on a background of iodine deficiency in order to study the efficacy of using potassium iodide in these patients. Methods and results. Iodine deficiency was detected by level of iodine in urine, level of TSH, free T4 and free T3. Also was determined motor-evacuational function of the stomach according to 13C-octanoic breath test and levels of regulatory peptides (gastrin, cholecystokinin-pankreozymin and pepsinogens). Conclusion. Positive dynamics of iodine absorption and motor-evacuational function of the stomach were found after 1 month of treatment. Decreasing frequency and duration of acid reflux and reducing pepsinogen levels and improvement of indicators of intestinal hormones were also found in these patiens. This shows the optimization of regulatory mechanisms and kinetics of upper gastrointestinal tract.

Keywords

• Gastroesophageal Reflux Disease
• Iodine
• Endemic Goiter
• Hormones