Frontiers in Physiology (Jun 2018)

Logical Modeling and Analysis of Cellular Regulatory Networks With GINsim 3.0

  • Aurélien Naldi,
  • Céline Hernandez,
  • Wassim Abou-Jaoudé,
  • Pedro T. Monteiro,
  • Claudine Chaouiya,
  • Denis Thieffry

DOI
https://doi.org/10.3389/fphys.2018.00646
Journal volume & issue
Vol. 9

Abstract

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The logical formalism is well adapted to model large cellular networks, in particular when detailed kinetic data are scarce. This tutorial focuses on this well-established qualitative framework. Relying on GINsim (release 3.0), a software implementing this formalism, we guide the reader step by step toward the definition, the analysis and the simulation of a four-node model of the mammalian p53-Mdm2 network.

Keywords