npj Breast Cancer (Feb 2017)
A functionally significant SNP in TP53 and breast cancer risk in African-American women
- Maureen E. Murphy,
- Song Liu,
- Song Yao,
- Dezheng Huo,
- Qin Liu,
- Sonia C. Dolfi,
- Kim M. Hirshfield,
- Chi-Chen Hong,
- Qiang Hu,
- Andrew F. Olshan,
- Temidayo O. Ogundiran,
- Clement Adebamowo,
- Susan M. Domchek,
- Katherine L. Nathanson,
- Barbara Nemesure,
- Stefan Ambs,
- William J. Blot,
- Ye Feng,
- Esther M. John,
- Leslie Bernstein,
- Wei Zheng,
- Jennifer J. Hu,
- Regina G. Ziegler,
- Sarah Nyante,
- Sue A. Ingles,
- Michael F. Press,
- Sandra L. Deming,
- Jorge L. Rodriguez-Gil,
- Christopher A. Haiman,
- Olufunmilayo I. Olopade,
- Kathryn L. Lunetta,
- Julie R. Palmer,
- Christine B. Ambrosone
Affiliations
- Maureen E. Murphy
- Program in Molecular and Cellular Oncogenesis, The Wistar Institute
- Song Liu
- Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute
- Song Yao
- Department of Cancer Prevention and Control, Roswell Park Cancer Institute
- Dezheng Huo
- Department of Public Health Sciences, University of Chicago
- Qin Liu
- Program in Molecular and Cellular Oncogenesis, The Wistar Institute
- Sonia C. Dolfi
- Department of Medicine, Rutgers Robert Wood Johnson Medical School/Rutgers Cancer Institute of New Jersey
- Kim M. Hirshfield
- Department of Medicine, Rutgers Robert Wood Johnson Medical School/Rutgers Cancer Institute of New Jersey
- Chi-Chen Hong
- Department of Cancer Prevention and Control, Roswell Park Cancer Institute
- Qiang Hu
- Department of Biostatistics and Bioinformatics, Roswell Park Cancer Institute
- Andrew F. Olshan
- University of North Carolina Lineberger Comprehensive Cancer Center
- Temidayo O. Ogundiran
- Department of Surgery, College of Medicine, University of Ibadan
- Clement Adebamowo
- Department of Epidemiology & Public Health, University of Maryland School of Medicine
- Susan M. Domchek
- Department of Medicine, Abramson Cancer Center, The Perelman School of Medicine at the University of Pennsylvania
- Katherine L. Nathanson
- Department of Medicine, Abramson Cancer Center, The Perelman School of Medicine at the University of Pennsylvania
- Barbara Nemesure
- Department of Family, Population and Preventive Medicine, Stony Brook University
- Stefan Ambs
- Laboratory of Human Carcinogenesis, National Cancer Institute
- William J. Blot
- International Epidemiology Institute
- Ye Feng
- Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
- Esther M. John
- Cancer Prevention Institute of California
- Leslie Bernstein
- Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute
- Wei Zheng
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Jennifer J. Hu
- Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami Miller School of Medicine
- Regina G. Ziegler
- Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute
- Sarah Nyante
- Department of Epidemiology, Gillings School of Global Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina
- Sue A. Ingles
- Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
- Michael F. Press
- Department of Pathology, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
- Sandra L. Deming
- Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine
- Jorge L. Rodriguez-Gil
- Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami Miller School of Medicine
- Christopher A. Haiman
- Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California
- Olufunmilayo I. Olopade
- Department of Medicine, University of Chicago
- Kathryn L. Lunetta
- Department of Biostatistics, Boston University
- Julie R. Palmer
- Slone Epidemiology Center at Boston University
- Christine B. Ambrosone
- Department of Medicine, Rutgers Robert Wood Johnson Medical School/Rutgers Cancer Institute of New Jersey
- DOI
- https://doi.org/10.1038/s41523-017-0007-9
- Journal volume & issue
-
Vol. 3,
no. 1
pp. 1 – 4
Abstract
Genetics: Variant may increase cancer risk in pre-menopausal black women A gene variant found in people of African descent may increase the risk of breast cancer—but only among pre-menopausal women. In a study of more than 14,000 women of African ancestry, a team led by Maureen Murphy from the Wistar Institute in Philadelphia, Pennsylvania, USA, and Christine Ambrosone from Roswell Park Cancer Institute in Buffalo, NY, USA, tested for an association between breast cancer and a rare genetic polymorphism in the TP53 gene that’s found almost exclusively in African-descent populations. This variant alters the p53 tumor suppressor protein and has been shown to increase cancer risk in a mouse model. Murphy and colleagues showed that the variant increased risk by about 72% in women who had not yet experienced menopause—which could help explain the earlier onset of the disease among women of African ancestry.
