A novel asymmetric synthesis of cinacalcet hydrochloride

Abstract

A novel route to asymmetric synthesis of cinacalcet hydrochloride by the application of (R)-tert-butanesulfinamide and regioselective N-alkylation of the naphthyl ethyl sulfinamide intermediate is described.

Keywords

• asymmetric synthesis
• (R)-tert-butanesulfinamide
• cinacalcet hydrochloride
• naphthyl ethyl sulfinamide
• regioselective N-alkylation