Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos

Yura Lee; Han Chen; Wei Chen; Qibin Qi; Majid Afshar; Jianwen Cai; Martha L. Daviglus; Bharat Thyagarajan; Kari E. North; Stephanie J. London; Eric Boerwinkle; Juan C. Celedón; Robert C. Kaplan; Bing Yu

doi:10.3390/metabo12040359

Metabolites (Apr 2022)

Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos

Yura Lee,
Han Chen,
Wei Chen,
Qibin Qi,
Majid Afshar,
Jianwen Cai,
Martha L. Daviglus,
Bharat Thyagarajan,
Kari E. North,
Stephanie J. London,
Eric Boerwinkle,
Juan C. Celedón,
Robert C. Kaplan,
Bing Yu

Affiliations

Yura Lee: Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Han Chen: Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Wei Chen: Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA
Qibin Qi: Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Majid Afshar: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
Jianwen Cai: Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA
Martha L. Daviglus: Institute of Minority Health Research, University of Illinois College of Medicine, Chicago, IL 60612, USA
Bharat Thyagarajan: Department of Laboratory Medicine and Pathology, University of Minnesota, MMC 609, 420 Delaware Street, Minneapolis, MN 55455, USA
Kari E. North: Department of Epidemiology and Carolina Center for Genome Sciences, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA
Stephanie J. London: Department of Health and Human Services, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Eric Boerwinkle: Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA
Juan C. Celedón: Department of Pediatrics, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15224, USA
Robert C. Kaplan: Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI 53726, USA
Bing Yu: Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA

DOI: https://doi.org/10.3390/metabo12040359
Journal volume & issue: Vol. 12, no. 4
p. 359

Abstract

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Asthma disproportionally affects Hispanic and/or Latino backgrounds; however, the relation between circulating metabolites and asthma remains unclear. We conducted a cross-sectional study associating 640 individual serum metabolites, as well as twelve metabolite modules, with asthma in 3347 Hispanic/Latino background participants (514 asthmatics, 15.36%) from the Hispanic/Latino Community Health Study/Study of Latinos. Using survey logistic regression, per standard deviation (SD) increase in 1-arachidonoyl-GPA (20:4) was significantly associated with 32% high odds of asthma after accounting for clinical risk factors (p = 6.27 × 10−5), and per SD of the green module, constructed using weighted gene co-expression network, was suggestively associated with 25% high odds of asthma (p = 0.006). In the stratified analyses by sex and Hispanic and/or Latino backgrounds, the effect of 1-arachidonoyl-GPA (20:4) and the green module was predominantly observed in women (OR = 1.24 and 1.37, p p FADS2) affected the levels of 1-arachidonoyl-GPA (20:4), and Mendelian Randomization analyses revealed that high genetically regulated 1-arachidonoyl-GPA (20:4) levels were associated with increased odds of asthma (p < 0.001). The findings reinforce a molecular basis for asthma etiology, and the potential causal effect of 1-arachidonoyl-GPA (20:4) on asthma provides an opportunity for future intervention.

Published in Metabolites

ISSN: 2218-1989 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Microbiology
Website: http://www.mdpi.com/journal/metabolites

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