Nature Communications (Mar 2020)

The substrate specificity switch FlhB assembles onto the export gate to regulate type three secretion

  • Lucas Kuhlen,
  • Steven Johnson,
  • Andreas Zeitler,
  • Sandra Bäurle,
  • Justin C. Deme,
  • Joseph J.  E. Caesar,
  • Rebecca Debo,
  • Joseph Fisher,
  • Samuel Wagner,
  • Susan M. Lea

DOI
https://doi.org/10.1038/s41467-020-15071-9
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 10

Abstract

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Export of proteins by type three secretion systems occurs through an export gate that is localized in the periplasm. Here, the authors present the cryo-EM structure of the Vibrio mimicus export gate complex with FlhB, which plays a major role in switching of the specificity of secretion substrates and propose a mechanism for export gate opening.