Frontiers in Neuroscience (Sep 2019)
Proceedings of the Sixth Deep Brain Stimulation Think Tank Modulation of Brain Networks and Application of Advanced Neuroimaging, Neurophysiology, and Optogenetics
- Adolfo Ramirez-Zamora,
- James Giordano,
- Edward S. Boyden,
- Edward S. Boyden,
- Edward S. Boyden,
- Viviana Gradinaru,
- Aysegul Gunduz,
- Philip A. Starr,
- Sameer A. Sheth,
- Cameron C. McIntyre,
- Michael D. Fox,
- Jerrold Vitek,
- Vinata Vedam-Mai,
- Umer Akbar,
- Leonardo Almeida,
- Helen M. Bronte-Stewart,
- Helen S. Mayberg,
- Nader Pouratian,
- Aryn H. Gittis,
- Annabelle C. Singer,
- Meaghan C. Creed,
- Gabriel Lazaro-Munoz,
- Mark Richardson,
- Marvin A. Rossi,
- Leopoldo Cendejas-Zaragoza,
- Pierre-Francois D’Haese,
- Winston Chiong,
- Ro’ee Gilron,
- Howard Chizeck,
- Andrew Ko,
- Kenneth B. Baker,
- Joost Wagenaar,
- Noam Harel,
- Wissam Deeb,
- Kelly D. Foote,
- Michael S. Okun
Affiliations
- Adolfo Ramirez-Zamora
- Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- James Giordano
- Neuroethics Studies Program, Department of Neurology and Department of Biochemistry, Georgetown University Medical Center, Washington, DC, United States
- Edward S. Boyden
- Media Laboratory, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States
- Edward S. Boyden
- Center for Neurobiological Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States
- Edward S. Boyden
- Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, United States
- Viviana Gradinaru
- Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, United States
- Aysegul Gunduz
- Department of Neuroscience and Department of Biomedical Engineering and Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Philip A. Starr
- Graduate Program in Neuroscience, Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Sameer A. Sheth
- Department of Neurological Surgery, Baylor College of Medicine, Houston, TX, United States
- Cameron C. McIntyre
- 0Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States
- Michael D. Fox
- 1Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States
- Jerrold Vitek
- 2Department of Neurology, University of Minnesota, Minneapolis, MN, United States
- Vinata Vedam-Mai
- 3Department of Neurosurgery, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Umer Akbar
- 4Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Veterans Affairs Medical Center, Brown Institute for Brain Science, Brown University, Providence, RI, United States
- Leonardo Almeida
- Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Helen M. Bronte-Stewart
- 5Department of Neurology and Department of Neurological Sciences and Department of Neurosurgery, Stanford University, Stanford, CA, United States
- Helen S. Mayberg
- 6Department of Neurology and Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, NY, United States
- Nader Pouratian
- 7Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
- Aryn H. Gittis
- 8Biological Sciences and Center for Neural Basis of Cognition, Carnegie Mellon University, Pittsburgh, PA, United States
- Annabelle C. Singer
- 9Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Emory University School of Medicine, Atlanta, GA, United States
- Meaghan C. Creed
- 0Department of Pharmacology, University of Maryland School of Medicine, Baltimore, MD, United States
- Gabriel Lazaro-Munoz
- 1Center for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX, United States
- Mark Richardson
- 2Center for the Neural Basis of Cognition, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States
- Marvin A. Rossi
- 3Department of Diagnostic Radiology and Nuclear Medicine, Rush University Medical Center, Chicago, IL, United States
- Leopoldo Cendejas-Zaragoza
- 4Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, United States
- Pierre-Francois D’Haese
- 5Electrical Engineering, Vanderbilt University, Nashville, TN, United States
- Winston Chiong
- 6Department of Neurology, University of California, San Francisco, San Francisco, CA, United States
- Ro’ee Gilron
- Graduate Program in Neuroscience, Department of Neurological Surgery, Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, United States
- Howard Chizeck
- 7Graduate Program in Neuroscience, Department of Electrical Engineering, University of Washington, Seattle, WA, United States
- Andrew Ko
- 8Department of Neurological Surgery, University of Washington, Seattle, WA, United States
- Kenneth B. Baker
- 9Movement Disorders Program, Cleveland Clinic Foundation, Cleveland, OH, United States
- Joost Wagenaar
- 0Department of Neurology, Center for Neuroengineering and Therapeutics, University of Pennsylvania, Philadelphia, PA, United States
- Noam Harel
- 1Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States
- Wissam Deeb
- Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Kelly D. Foote
- 3Department of Neurosurgery, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- Michael S. Okun
- Department of Neurology, Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States
- DOI
- https://doi.org/10.3389/fnins.2019.00936
- Journal volume & issue
-
Vol. 13
Abstract
The annual deep brain stimulation (DBS) Think Tank aims to create an opportunity for a multidisciplinary discussion in the field of neuromodulation to examine developments, opportunities and challenges in the field. The proceedings of the Sixth Annual Think Tank recapitulate progress in applications of neurotechnology, neurophysiology, and emerging techniques for the treatment of a range of psychiatric and neurological conditions including Parkinson’s disease, essential tremor, Tourette syndrome, epilepsy, cognitive disorders, and addiction. Each section of this overview provides insight about the understanding of neuromodulation for specific disease and discusses current challenges and future directions. This year’s report addresses key issues in implementing advanced neurophysiological techniques, evolving use of novel modulation techniques to deliver DBS, ans improved neuroimaging techniques. The proceedings also offer insights into the new era of brain network neuromodulation and connectomic DBS to define and target dysfunctional brain networks. The proceedings also focused on innovations in applications and understanding of adaptive DBS (closed-loop systems), the use and applications of optogenetics in the field of neurostimulation and the need to develop databases for DBS indications. Finally, updates on neuroethical, legal, social, and policy issues relevant to DBS research are discussed.
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